AN ONCOLYTIC VACCINIA VIRUS ENCODING HYALURONIDASE RESHAPES THE EXTRACELLULAR MATRIX TO ENHANCE CANCER CHEMOTHERAPY AND IMMUNOTHERAPY

An oncolytic vaccinia virus encoding hyaluronidase reshapes the extracellular matrix to enhance cancer chemotherapy and immunotherapy

Background The redundant extracellular matrix (ECM) within tumor microenvironment (TME) such as hyaluronic acid (HA) often impairs intratumoral dissemination of antitumor drugs.Oncolytic viruses (OVs) are being studied extensively for cancer therapy either alone or in conjunction with chemotherapy and immunotherapy.Here, we designed a novel recombi

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Rapid Identification of Adulteration in Edible Vegetable Oils Based on Low-Field Nuclear Magnetic Resonance Relaxation Fingerprints

Most current approaches applied for the essential identification of adulteration in edible vegetable oils are of limited practical benefit because they require long analysis times, professional training, and costly instrumentation.The present work addresses this issue by developing a novel simple, Console Wire accurate, and rapid identification app

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